Nanocarriers for siRNA Therapy

Small interfering RNAs (siRNAs) therapy has opened exceptional advantageous opportunity for the treatment of diseases. Usually naked siRNA are subjected to internal harsh environment and rapidly degraded by RNases after administration. To overcome this issue various nanodelivery platforms have been developed and utilized in drug delivery due to narrowed size distribution, improved bioavailability and site specific target, impacting lowering of doses. To amenable the delivery of siRNA, various nanovehicles are designed and complexed with specific siRNA for protecting the siRNA payloads and avoiding nonspecific delivery. This review describes the recent developments of siRNA-complexed nanovehicles, which can probably carry forward to the next generation for their successful clinical translation.